Scientists have long debated the effects of caffeine on blood pressure. Some studies have shown no effect, but one from Duke University Medical Center found that caffeine consumption of 500 mg three 8 ounce cups of coffee blood pressure by 4 mmHg, and that effect lasted until bedtime. For reference, 8 ounces of drip coffee contain 100 to 125 mg of caffeine; the same amount of tea, 50 mg; an equal quantity of cola, about 40 mg.

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